Ruthenium in PDB 8ffq: Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red

The binding sites of Ruthenium atom in the Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red (pdb code 8ffq). This binding sites where shown within 5.0 Angstroms radius around Ruthenium atom.
In total 3 binding sites of Ruthenium where determined in the Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red, PDB code: 8ffq:
Jump to Ruthenium binding site number: 1; 2; 3;

Ruthenium binding site 1 out of 3 in the Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 1 of Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru803 b:30.0 occ:1.00 RU2 A:R2R803 0.0 30.0 1.0 O13 A:R2R803 1.8 30.0 1.0 O06 A:R2R803 1.9 30.0 1.0 N05 A:R2R803 2.0 30.0 1.0 N04 A:R2R803 2.0 30.0 1.0 N01 A:R2R803 2.0 30.0 1.0 N03 A:R2R803 2.0 30.0 1.0 RU1 A:R2R803 3.5 30.0 1.0 RU3 A:R2R803 3.7 30.0 1.0 N18 A:R2R803 4.0 30.0 1.0 N17 A:R2R803 4.0 30.0 1.0 N19 A:R2R803 4.0 30.0 1.0 N16 A:R2R803 4.0 30.0 1.0 N11 A:R2R803 4.3 30.0 1.0 N10 A:R2R803 4.3 30.0 1.0 N09 A:R2R803 4.3 30.0 1.0 N12 A:R2R803 4.3 30.0 1.0 OG1 C:THR539 4.7 22.2 1.0 OG1 A:THR539 4.7 22.2 1.0 OG1 B:THR539 4.7 22.2 1.0 OG1 D:THR539 4.7 22.2 1.0

Ruthenium binding site 2 out of 3 in the Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 2 of Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru803 b:30.0 occ:1.00 RU3 A:R2R803 0.0 30.0 1.0 O06 A:R2R803 1.9 30.0 1.0 N08 A:R2R803 2.0 30.0 1.0 N10 A:R2R803 2.0 30.0 1.0 N09 A:R2R803 2.0 30.0 1.0 N12 A:R2R803 2.0 30.0 1.0 N11 A:R2R803 2.0 30.0 1.0 RU2 A:R2R803 3.7 30.0 1.0 CD1 B:ILE575 4.2 11.7 1.0 CD1 C:ILE575 4.2 11.7 1.0 CD1 D:ILE575 4.2 11.7 1.0 CD1 A:ILE575 4.2 11.7 1.0 N05 A:R2R803 4.3 30.0 1.0 N01 A:R2R803 4.3 30.0 1.0 N04 A:R2R803 4.3 30.0 1.0 N03 A:R2R803 4.3 30.0 1.0 OD1 C:ASN572 4.7 27.8 1.0 OD1 B:ASN572 4.7 27.8 1.0 OD1 D:ASN572 4.7 27.8 1.0 OD1 A:ASN572 4.7 27.8 1.0

Ruthenium binding site 3 out of 3 in the Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 3 of Wildtype Rabbit TRPV5 Into Nanodiscs in the Presence of Pi(4,5)P2 and Ruthenium Red within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru803 b:30.0 occ:1.00 RU1 A:R2R803 0.0 30.0 1.0 O13 A:R2R803 1.7 30.0 1.0 N18 A:R2R803 2.0 30.0 1.0 N17 A:R2R803 2.0 30.0 1.0 N16 A:R2R803 2.0 30.0 1.0 N19 A:R2R803 2.0 30.0 1.0 N15 A:R2R803 2.0 30.0 1.0 RU2 A:R2R803 3.5 30.0 1.0 N04 A:R2R803 4.0 30.0 1.0 N01 A:R2R803 4.0 30.0 1.0 N03 A:R2R803 4.0 30.0 1.0 N05 A:R2R803 4.0 30.0 1.0 OG1 C:THR539 4.3 22.2 1.0 OG1 B:THR539 4.3 22.2 1.0 OG1 A:THR539 4.3 22.2 1.0 OG1 D:THR539 4.3 22.2 1.0 O A:THR539 4.4 39.6 1.0 O C:THR539 4.4 39.6 1.0 O B:THR539 4.4 39.6 1.0 O D:THR539 4.4 39.6 1.0 CB C:THR539 5.0 21.0 1.0 CB B:THR539 5.0 21.0 1.0 CB A:THR539 5.0 21.0 1.0 CB D:THR539 5.0 21.0 1.0

R.A.Pumroy, J.J.De Jesus-Perez, A.D.Protopopova, J.A.Rocereta, E.C.Fluck, T.Fricke, B.H.Lee, T.Rohacs, A.Leffler, V.Moiseenkova-Bell. Molecular Details of Ruthenium Red Pore Block in Trpv Channels. Embo Rep. 2024.
ISSN: ESSN 1469-3178
PubMed: 38225355
DOI: 10.1038/S44319-023-00050-0