Ruthenium in PDB 6v3c: K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure

The structure of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure, PDB code: 6v3c was solved by L.Pope, M.Lolicato, D.L.Minor, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	14.98 / 3.51
Space group	P 21 21 21
Cell size a, b, c (Å), α, β, γ (°)	67.737, 120.708, 127.274, 90.00, 90.00, 90.00
R / Rfree (%)	30.2 / 32.5

The structure of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure also contains other interesting chemical elements:

Cadmium	(Cd)	3 atoms
Potassium	(K)	5 atoms

The binding sites of Ruthenium atom in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure (pdb code 6v3c). This binding sites where shown within 5.0 Angstroms radius around Ruthenium atom.
In total 2 binding sites of Ruthenium where determined in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure, PDB code: 6v3c:
Jump to Ruthenium binding site number: 1; 2;

Ruthenium binding site 1 out of 2 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 1 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru401 b:0.8 occ:0.50 RU A:RU3401 0.0 0.8 0.5 N4 A:RU3401 1.8 0.8 0.5 N7 A:RU3401 1.8 0.1 0.5 N6 A:RU3401 1.8 0.0 0.5 N5 A:RU3401 1.8 0.3 0.5 O3 A:RU3401 1.8 0.5 0.5 O A:RU3401 1.8 0.8 0.5 C1 A:RU3401 2.9 0.3 0.5 N A:RU3401 3.3 0.1 0.5 RU1 A:RU3401 3.4 0.0 0.5 OD2 A:ASP110 3.5 0.6 1.0 N1 A:RU3401 3.6 0.9 0.5 O4 A:RU3401 3.7 0.5 0.5 N3 A:RU3401 4.1 0.8 0.5 CG A:ASP110 4.2 0.9 1.0 N2 A:RU3401 4.3 0.9 0.5 OD1 A:ASP110 4.5 0.6 1.0 OD1 B:ASP110 4.5 0.4 1.0

Ruthenium binding site 2 out of 2 in the K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 2 of K2P2.1(Trek-1)I110D:RU360 Bound Channel Structure within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru401 b:0.0 occ:0.50 RU1 A:RU3401 0.0 0.0 0.5 N A:RU3401 1.8 0.1 0.5 N2 A:RU3401 1.8 0.9 0.5 N3 A:RU3401 1.8 0.8 0.5 N1 A:RU3401 1.8 0.9 0.5 O1 A:RU3401 1.8 0.0 0.5 O A:RU3401 1.8 0.8 0.5 C A:RU3401 2.8 0.9 0.5 O2 A:RU3401 3.2 0.4 0.5 N4 A:RU3401 3.3 0.8 0.5 RU A:RU3401 3.4 0.8 0.5 OD1 B:ASP110 3.4 0.4 1.0 N7 A:RU3401 3.6 0.1 0.5 OD2 B:ASP110 3.9 0.4 1.0 N5 A:RU3401 4.0 0.3 0.5 CG B:ASP110 4.1 0.9 1.0 OD1 A:ASP110 4.1 0.6 1.0 N6 A:RU3401 4.3 0.0 0.5 OD2 A:ASP110 4.5 0.6 1.0 CG A:ASP110 4.7 0.9 1.0

L.Pope, M.Lolicato, D.L.Minor Jr.. Polynuclear Ruthenium Amines Inhibit K2PCHANNELS Via A "Finger in the Dam" Mechanism. Cell Chem Biol 2020.
ISSN: ESSN 2451-9456
PubMed: 32059793
DOI: 10.1016/J.CHEMBIOL.2020.01.011