Ruthenium in PDB 6ftv: X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A

All present enzymatic activity of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A:
1.16.3.1;

The structure of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A, PDB code: 6ftv was solved by A.Merlino, G.Ferraro, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	105.30 / 1.58
Space group	F 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	182.380, 182.380, 182.380, 90.00, 90.00, 90.00
R / Rfree (%)	14.2 / 18.3

The structure of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A also contains other interesting chemical elements:

Magnesium	(Mg)	10 atoms
Chlorine	(Cl)	7 atoms

The binding sites of Ruthenium atom in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A (pdb code 6ftv). This binding sites where shown within 5.0 Angstroms radius around Ruthenium atom.
In total 2 binding sites of Ruthenium where determined in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A, PDB code: 6ftv:
Jump to Ruthenium binding site number: 1; 2;

Ruthenium binding site 1 out of 2 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 1 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru217 b:69.2 occ:0.25 O A:HOH488 2.2 32.9 0.2 NE2 A:HIS105 2.3 29.4 0.5 O A:HOH531 2.4 52.0 0.2 O A:HOH523 2.4 55.6 0.2 CE1 A:HIS105 2.6 35.1 0.5 CD2 A:HIS105 3.6 35.1 0.5 ND2 A:ASN109 3.7 27.0 0.5 O A:HOH534 3.8 47.1 0.5 ND1 A:HIS105 3.8 36.0 0.5 OD1 A:ASN109 3.9 30.3 0.5 O A:HOH384 4.2 49.4 1.0 CG A:ASN109 4.3 21.9 0.5 CG A:HIS105 4.4 29.0 0.5 OD1 A:ASN109 4.9 47.9 0.5

Ruthenium binding site 2 out of 2 in the X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A


Mono view


Stereo pair view

A full contact list of Ruthenium with other atoms in the Ru binding site number 2 of X-Ray Structure of Human Heavy Chain Ferritin in Complex with Nami A within 5.0Å range: probe atom residue distance (Å) B Occ A:Ru217 b:44.8 occ:0.35 O A:HOH523 2.3 34.6 0.3 O A:HOH637 2.3 34.2 0.3 O A:HOH301 2.4 41.3 0.3 O A:HOH488 2.4 33.0 0.3 O A:HOH531 2.4 45.0 0.3 NE2 A:HIS105 2.5 45.2 0.5 CE1 A:HIS105 2.8 46.5 0.5 O A:HOH420 3.0 34.0 0.7 O A:HOH586 3.5 22.1 0.5 CD2 A:HIS105 3.7 45.9 0.5 ND1 A:HIS105 4.0 43.8 0.5 CG A:HIS105 4.4 34.4 0.5 O A:HOH563 5.0 93.2 1.0

S.Ciambellotti, A.Pratesi, M.Severi, G.Ferraro, E.Alessio, A.Merlino, L.Messori. The Nami A - Human Ferritin System: A Biophysical Characterization. Dalton Trans V. 47 11429 2018.
ISSN: ESSN 1477-9234
PubMed: 30063237
DOI: 10.1039/C8DT00860D