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Ruthenium in PDB 3cst: Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
Enzymatic activity of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
All present enzymatic activity of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2:
2.7.1.153;
2.7.1.153;
Protein crystallography data
The structure of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst
was solved by
P.Xie,
R.Marmorstein,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 50.00 / 3.20 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 145.114, 68.318, 107.029, 90.00, 95.14, 90.00 |
| R / Rfree (%) | 26.4 / 30.5 |
Other elements in 3cst:
The structure of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2 also contains other interesting chemical elements:
| Fluorine | (F) | 1 atom |
Ruthenium Binding Sites:
The binding sites of Ruthenium atom in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
(pdb code 3cst). This binding sites where shown within
5.0 Angstroms radius around Ruthenium atom.
In total only one binding site of Ruthenium was determined in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst:
In total only one binding site of Ruthenium was determined in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2, PDB code: 3cst:
Ruthenium binding site 1 out of 1 in 3cst
Go back to
Ruthenium Binding Sites List in 3cst
Ruthenium binding site 1 out
of 1 in the Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Ruthenium with other atoms in the Ru binding
site number 1 of Crystal Structure of PI3K P110GAMMA Catalytical Domain in Complex with Organoruthenium Inhibitor E5E2 within 5.0Å range:
|
Reference:
P.Xie,
D.S.Williams,
G.E.Atilla-Gokcumen,
L.Milk,
M.Xiao,
K.S.Smalley,
M.Herlyn,
E.Meggers,
R.Marmorstein.
Structure-Based Design of An Organoruthenium Phosphatidyl-Inositol-3-Kinase Inhibitor Reveals A Switch Governing Lipid Kinase Potency and Selectivity. Acs Chem.Biol. V. 3 305 2008.
ISSN: ISSN 1554-8929
PubMed: 18484710
DOI: 10.1021/CB800039Y
Page generated: Thu Oct 10 12:47:33 2024
ISSN: ISSN 1554-8929
PubMed: 18484710
DOI: 10.1021/CB800039Y
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